Hi,
Could you please let us know the exact version of BlackBerry Enterprise Server that you are running (e.g. 4.1.4.26), and what version of Domino are you running?
As a starting point I would highly recommend watching the "Advanced Debug Log Analysis" webcast which I have provided a link for below:
Overview
Understanding debug log files of the various components in the BlackBerry® Enterprise Server™ allows administrators to quickly determine issues with their BlackBerry Infrastructure. This webcast will overview the anatomy of a debug log file in BlackBerry Enterprise Server v4.0/v4.1and hone in on specifics. An explanation of the communications and interaction between the server components will also be discussed in relation to the log files.
Advanced Debug Log Analysis Webcast
Thanks,
Gary